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Friday, May 1, 2009

2 weeks of neglect on my blog = great thesis progress.

I wonder if my blogging output is inversely proportional to my progress on my thesis. I stopped writing two weeks ago for a little break, and ended up making big steps forward. The vast amount of my work went into FindPeaks, which included the following:

  • A complete threaded Saturation analysis for next-gen libraries.

  • A method of comparing next-gen libraries to identify peaks that are statistically significant outliers. (It's also symmetic, unlike a linear regression based methods.)

  • A better control method

  • A whole new way of analysing WTSS data, which gives statistically valid expression differences

And, of course many many other changes. Not everything is bug-free, yet, but it's getting there. All that's left on my task list are debugging a couple of things in the compare mode, relating to peaks present in only one of the two librarires, and an upgrade to my FDR cutoff prediction methods. Once those are done, I think I'll be ready to push out FindPeaks 4.0. YAY!

Actually, what was surprising to me was the sheer amount of work that I've done on this since January. I compiled the change list since my last "quarterly report" for a project that used FindPeaks (but doesn't support it, ironically.... why am I doing reports for them again?) and came up with 24 pages of commit messages - over 575 commits. Considering the amount of work I've done on my actual projects, away from FindPeaks, I think I've been pretty darn productive.

Yes, I'm going to take this opportunity to pat myself on the back in public for a whole 2 seconds... ok, done.

So, overall, blogging may not have been distracting me from my work, as even at the height of my blogging (around AGBT), I was still getting lots done, but the past two weeks have really been a help. I'll be back to blogging all the good stuff on monday. And I'm looking forward to doing some writing now, on some of the cool things in FP4.0 that haven't made it into the manual... yet.

Anyone want some fresh ChIP-Seq results? (-;

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